Dating kp st
Further studies are required to understand the potential biological significance of this event in vitro .We also identified the KP-6 cell line as a novel hyperdiploid HMCL established from an extramedullary site of an advanced hyperdiploid patient.Reliable model systems are critical for investigating the genetic and molecular drivers of disease pathogenesis.Although the number of cell line model systems for multiple myeloma is extensive, recent studies showed patient tumors and cell lines clustering separately based on gene expression profiles.Built in 2002 has 4 bedrooms, 2 bathrooms and attached 2 car garage. This property was built in 2002 and last sold on January 30, 2018 for 4,300.Open concept with dining room, kitchen and living room all flowing together. The presence of trisomies for at least four of the odd-numbered chromosomes is characteristic of a hyperdiploid myeloma patient.
Of particular interest, ubiquitous 7q gains were an unexpected unifying event across all patient tumors and their HMCLs.The patient diagnostic and relapse tumors showed 58% similarity based on CNAs while the diagnostic and relapse tumors contained 8% and 34% unique events respectively.These results indicate that established HMCLs are no more divergent from their primary cells as is the same patient's relapse material.Furthermore, the hyperdiploid karyotype, present in approximately 50% of myeloma patients, is also extremely underrepresented in established human myeloma cell lines (HMCLs): only one of 59 HMCLs contains this phenotype.These data suggests that the average HMCL does not accurately represent the average myeloma patient and questions the validity of using HMCLs as model systems.
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However, most HMCLs were established from patients with pleural effusions or plasma cell leukemia, which are highly progressed and rare forms of myeloma.