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This is significant because inhibition of ccc DNA is considered essential in achieving a complete cure.
Block is confident that a drug that can accomplish this will be developed.
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How far are we from finding a cure for hepatitis B?
We are close, said Timothy Block, Ph D, president and co-founder of the Hepatitis B Foundation and its research arm, the Baruch S. He points out that hepatitis C, once thought to be incurable, is today cured with new combination treatments.
“We are committing everything we have, every resource at our disposal, to developing the therapies that will ultimately improve the lives of all people living with hepatitis B worldwide and ultimately relegate hepatitis B to the history books.” Drugs currently in development at the Blumberg Institute ccc DNA Inhibitors: Blumberg is the only group to identify the first small molecule inhibitor of HBV ccc DNA, which has now been made highly active and is licensed to Arbutus Biopharma for further development.
Capsid Inhibitors, “YES Kinase” Inhibitors: It is using high-throughput screens and computer modeling to design and produce targeted drugs that include capsid inhibitors for hepatitis B and “YES kinase” inhibitors for liver cancer.
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Adding to its drug arsenal, Blumberg researchers have used computer modeling to design and produce targeted drugs against hepatitis B and liver cancer.